Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis

Dithranol is one of the oldest and most efficient drugs used in treatment psoriasis. One challenges with using dithranol its photostability, because it easily degrades when exposed to light. This study investigated potential coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing photostability remote-controlled drug delivery psoriasis therapy. We have shown that titanium oxide nanoparticles (reflecting absorbing ultra-violet light) PVA-based sheath part can increase photostability. Incorporation magnetic into PCL-based core enables release control via an external radio-frequency field. The application field generates heat be rate drugs. Our approach therefore offers non-invasive remotely controlled hold promise development new topical formulations dithranol.